The aim of the present study is to investigate anticonvulsant effect of the Tolperisone (10 mg/kg) on electrically and chemically induced seizures. The Tolperisone (10 mg/kg) of was studied for its anticonvulsant effect on maximal electroshock-induced seizures and Pentylenetetrazole and Isoniazid induced seizures in Rats. The latency of tonic convulsions and the number of animals protected from tonic convulsions were noted. Tolperisone significantly reduced the duration of seizures induced by maximal electroshock (MES). The same doses also protected animals from Pentylenetetrazole-induced tonic seizures and significantly delayed the onset of tonic seizures produced by Isoniazid. The data suggest that the Tolperisone may produce its anticonvulsant effects via non-specific mechanisms since it reduced the duration of seizures produced by maximal electroshock as well as delayed the latency of seizures produced by Pentylenetetrazole and Isoniazid.
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